A dose of the Pfizer-BioNTech COVID-19 vaccine is given to a recipient at a vaccination site in Vancouver Thursday, March 11, 2021. THE CANADIAN PRESS/Jonathan Hayward

A dose of the Pfizer-BioNTech COVID-19 vaccine is given to a recipient at a vaccination site in Vancouver Thursday, March 11, 2021. THE CANADIAN PRESS/Jonathan Hayward

Fatigue, soreness, fever: experts say some side effects mean vaccines are working

Data from Health Canada shows 0.085 per cent of doses resulted in an adverse reaction

Sore arm, fatigue, muscle pain and fever are some of the side effects being reported in those receiving COVID-19 vaccines, and experts say that’s mostly a good thing.

Vaccines are supposed to trigger an immune response, they say. That’s how you know they’re working.

“If you have a vaccine that doesn’t produce a reaction in people, the resulting immune response is weaker,” said Earl Brown, a microbiologist with the University of Ottawa.

Brown says vaccines work by stimulating our immune cells to grow and communicate with each other, giving directions on where to set up for an impending attack by the virus. That results in inflammation, with some of those cells traveling to lymph nodes and causing swelling.

The mRNA vaccines from Pfizer-BioNTech and Moderna give immune cells instructions to make the COVID spike protein and produce antibodies. Viral vector vaccines like Oxford-AstraZeneca and Johnson & Johnson, meanwhile, force an immune response from the harmless version of the virus that’s injected with those jabs.

“The vaccines get your immune cells to start recruiting more of their buddies, saying ‘we’re making a new response. We need all you guys here,’” Brown said. “So the inflammation is good. It makes the immune system stronger.”

The World Health Organization says side effects to COVID vaccines have been mostly “mild to moderate and short-lasting” and include: fever, fatigue, headache, muscle pain, chills, diarrhea and pain at the injection site.

But how often do they happen?

Dr. Lynora Saxinger, an infectious disease expert with the University of Alberta, says cases of adverse effects are increasing because so many people are getting vaccinated now. The percentage of those that develop these mild to moderate side effects is still quite low compared to the number of people being immunized.

She notes that while more severe effects are possible — a small number have experienced serious allergic reactions — those events are rare.

Fever was common after the first dose of Pfizer and “very common” — defined as present in 10 per cent of participants or more — after the second dose. It was uncommon after the first dose of Moderna but very common after the second.

Brown says effects are generally more apparent following second doses because the body has built up a stronger immune response from the initial jab.

While Saxinger says a fever is a “strong reaction” to a vaccine, it shouldn’t last more than a few days. She also says taking anti-inflammatories before a vaccine to lessen possible effects isn’t advised, since you want to illicit that immune response.

“It looks like mRNA vaccines are particularly talented at mimicking infection,” she added. “That very targeted and strong immune response is what we ultimately want.”

READ MORE: Why is there no COVID vaccine for kids yet? A B.C. researcher breaks it down

Data from Health Canada shows 0.085 per cent of doses administered in the country from mid-December to March 5 resulted in an adverse reaction, with 0.009 per cent considered serious. Pain, redness and swelling at the vaccination site were the most common effects.

Most of those doses would have been mRNA vaccines, which are generally eliciting stronger reactions than the viral vector jabs.

Saxinger says that could be related to the initial efficacy of the vaccines. Whereas Pfizer and Moderna offer higher levels of effectiveness right away, AstraZeneca and Johnson & Johnson build up over time.

“It’s more of a slow-and-steady profile versus the hot-off-the-presses, quick response from the mRNA,” she said “So there’s a parallel there with the vigorousness of the initial immune reaction.”

But why do some people experience side effects while others don’t?

Brown says age is perhaps the biggest determining factor, noting older people, who tend to have less robust immune systems, report fewer reactions. Canada’s vaccine supply to date has mostly been administered to older populations.

The absence of side effects doesn’t mean the vaccine isn’t working, Brown added. Some people simply won’t show outward reactions.

News out of Europe last week caused concern over AstraZeneca’s product after some adverse events, including blood clots, were reported following vaccination. That spurred nearly a dozen countries to pause their use of the product while experts investigate a possible link.

Canadian health authorities said they were keeping a watchful eye on the Europeans investigations, but added there is no evidence the clots were caused by the vaccine.

AstraZeneca released a statement on Sunday saying a review of 17 million patients who received the shot in Europe and the U.K. showed no elevated risk of blood clotting.

Ann Taylor, the company’s chief medical officer, said there’s no increased risk of either pulmonary embolism, deep vein thrombosis or thrombocytopenia in any age group, gender, batch of vaccines or country.

The company said there are reports of 15 patients experiencing deep-vein thrombosis and 22 pulmonary embolisms as of March 8, which is much lower than what would occur naturally in a population of more than 17 million people.

Blood clots are fairly common, Saxinger says, so investigators will look at overall numbers of people who received the AstraZeneca vaccine compared to those who reported the condition.

“There’s so many people receiving vaccines daily that any health event that happens to anyone around the time they get their shot may or may not be related,” Saxinger said.

Brown says news of possible side effects shouldn’t dissuade people from getting vaccinated.

“Look at it as short-term, manageable discomfort without damage, compared to a real disease that could be life-altering or life-ending.”

The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

The Primary Urgent Care Centre on Martin Street opened on March 31, 2021. Interior Health is asking for funding from the Okanagan Similkameen Hospital District for the centre. (Brennan Phillips - Western News)
Interior Health seeks another shot at primary care funding

IH has sent a request for $1 million to the Okanagan Similkameen Hospital District

A syringe is loaded with COVID-19 vaccine at a vaccination clinic run by Vancouver Coastal Health, in Richmond, B.C., Saturday, April 10, 2021. THE CANADIAN PRESS/Jonathan Hayward
Interior Health announces 89 cases of COVID-19 in the region

Currently, there are 900 active cases in the region

B.C. wineries are open for indoor tasting despite new provincial health regulations. Photo- 
50th Parallel Winery, Instagram.
Indoor wine tastings still allowed in B.C., not considered a ‘social gathering’

“Tasting is really just part of the retail experience. The analogy I use is you wouldn’t buy a pair of pants without trying them on.”

Mainly clear and sunny skies are expected for the Okanagan-Shuswap region this week. (Maxpixels photo)
Warm, sunny week ahead in Okanagan-Shuswap

Daytime highs will reach the low 20s with mainly clear skies this week

Burnaby MLA Raj Chouhan presides as Speaker of the B.C. legislature, which opened it spring session April 12 with a speech from the throne. THE CANADIAN PRESS
B.C. NDP promises more health care spending, business support in 2021 budget

John Horgan government to ‘carefully return to balanced budgets’

A shop up on Grand Oro Road near Twin Lakes burned down on Monday. (Facebook)
Fire rips through shop in small South Okanagan town

The building was destroyed despite community efforts to fight the fire

The Save Sickle Point Committee, a grassroots community group, has teamed up Penticton’s Tempest Theatre and Film Society to release short film on Sickle Point. (Contributed)
WATCH: Conservation group releases short doc on saving South Okanagan’s ‘precious’ Sickle Point

Sickle Point, the last intact wetland near Skaha Lake, is facing the prospect of development

Protesters occupied a road leading to Fairy Creek Watershed near Port Renfrew. (Submitted photo)
B.C. First Nation says logging activist interference not welcome at Fairy Creek

Vancouver Island’s Pacheedaht concerned about increasing polarization over forestry activities

Skaha Lake Middle School. (File photo)
COVID exposure at Penticton middle school

Skaha Middle School is the latest in growing lists of exposure in the Okanagan

Flow Academy is not accepting membership applications from anybody who has received a dose of the vaccine, according to a password-protected membership application form. (Submitted image)
B.C. martial arts gym refusing patrons who have been vaccinated, wear masks

Interior Health has already issued a ticket to Flow Academy for non-compliance with public health orders

Forward Elan Bar Lev Wise of the West Kelowna Warriors (right, shown playing for the Vernon Vipers in 2019) has been suspended nine games by the B.C. Hockey League for being the instigator and aggressor in an after-the-game fight with Vernon’s Kjell Kjemhus Monday, April 12, at Kal Tire Place. Kjemhus was given a two-game suspension for his role. (Black Press - file photo)
West Kelowna Warriors forward handed lengthy suspension

Elan Bar Lev Wise fought Vernon Vipers forward Kjell Kjemhus after BCHL game was over Monday, April 12; Kjemhus suspended two games

A five-storey, 60-unit building has been proposed for 8709 Jubilee Rd. E., Summerland. The proposal will be the subject of a public hearing on March 22. (Image by GTA Architecture)
Zoning, OCP amendments adopted for Summerland housing development

Additional variances will be needed for controversial five-storey, 60-unit housing development

Guinevere, lovingly referred to by Jackee Sullivan and her family as Gwenny, is in need of a gynecological surgery. The family is raising money to help offset the cost of the procedure. (Jackee Sullivan/Special to Langley Advance Times)
Langley lizard’s owners raise funds for gynecological surgery

The young reptile is scheduled for operation on Tuesday

Most Read